Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.

Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.
A . 30 L/hr/70 Kg
B . 60 L/hr/70 Kg
C . 120 L/hr/70 Kg
D . 250 L/hr/70 Kg

Answer: A

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