What is the most appropriate management?

A 49-year-old woman presented with a slowly enlarging lump in her neck.

On examination, there was a 3.5-cm firm nodule in the left lobe of the thyroid gland, with no associated lymphadenopathy.

Investigations:

serum thyroid-stimulating hormone<0.05 mU/L (0.4C5.0)

serum free T426.0 pmol/L (10.0C22.0)

serum free T38.6 pmol/L (3.0C7.0)

An ultrasound scan showed an enlarged thyroid gland, with small nodules throughout. There was a larger hypoechoic 3.3-cm nodule with increased intranodular vascularity in the lower pole of the left lobe, with no associated lymphadenopathy.

What is the most appropriate management?
A . core biopsy of the thyroid nodule
B . fine-needle aspiration of the nodule
C . isotope uptake scan
D . partial thyroidectomy
E . radioactive iodine treatment