What is the most appropriate investigation?

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A 32-year-old woman presents with malaise fatigue and fever. She complains about weight loss. Exam: malar nasolabial fold can be seen.

What is the most appropriate investigation?

A. Anti-histone

B. Anti-centromere

C. Anti-ds DNA

D. Anti Jo

E. Anti Scl70

Answer: C

Explanation:

Features are suggestive of SLE. So most appropriate investigation from the given option DNA.