Which of the following drugs is most likely responsible for this?

A 27-year-old female with ovarian cancer is undergoing chemotherapy. She develops subsequent renal failure.

Which of the following drugs is most likely responsible for this?
A . Cyclophosphamide
B . Bleomycin
C . Cisplatin
D . Vinblastine
E . Vincristine

Answer: C

Explanation:

Cisplatin. All chemotherapeutics have similar generalized side effects related to their effects on rapidly growing cells. These include hair loss, nausea, and fatigue.

However, many chemotherapeutics have unique toxicities as well which are often tested. Cisplatin (C) is notable for its nephrotoxicity and ototoxicity. Cyclophosphamide (A) is known to cause hemorrhagic cystitis. This is a distinct process from nephrotoxicity. The most noteworthy side effect of bleomycin (B) is pulmonary toxicity that can lead to pulmonary fibrosis. Vinblastine (D) is known for bone marrow suppression. Vincristine (E) causes neuropathy.