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A 20-year-old man presented with a 6-month history of lethargy and weakness. His brother had been found to have adrenal failure at the age of 18. He had two sisters who were well and there was no other family history of endocrine autoimmune disease. On examination, his blood pressure was...

A 35-year-old woman was referred with a left lower thyroid lesion. She was asymptomatic. Examination confirmed the presence of a 2 ? 3-cm, firm, mobile, non-tender mass. Investigations: ultrasound-guided fine-needle aspiration biopsyThy 5 How is Thy 5 defined?A . abnormal, diagnostic of malignancyB . abnormal, suspicious (but not diagnostic of)...

A pregnant 36-year-old woman presented to the diabetes outpatient clinic. She had type 2 diabetes mellitus treated with diet, lifestyle changes and metformin 500 mg twice daily. On examination, her blood pressure was 128/84 mmHg. Investigations: haemoglobin A1c47 mmol/mol (20C42) urinary albumin: creatinine ratio1.6 mg/mmol (<3.5) Which is the best...

A 20-year-old man presented with a 6-month history of lethargy and weakness. His brother had been found to have adrenal failure at the age of 18. He had two sisters who were well and there was no other family history of endocrine autoimmune disease. On examination, his blood pressure was...

A 55-year-old dental nurse was referred for bone densitometry after sustaining a non-displaced fracture of the femur after falling down a step. She had experienced no other fractures. Her only medical problem was long-standing anaemia of unknown cause. The only family history was of persistent dental abscesses affecting her father....

A 26-year-old woman with previously well-controlled primary hypothyroidism had been an in patient for treatment of an eating disorder for the previous 6 weeks. She had a history of anaemia resulting from multiple vitamin deficiency and gastric erosions. She had been taking levothyroxine 125 micrograms daily for the previous 5...

A 61-year-old woman was referred to the blood pressure clinic because of refractory hypertension. One year previously, her blood pressure, urea and electrolytes had been normal. Her current therapy included verapamil modified-release 240 mg daily and doxazosin 16 mg daily. On examination, she was 1.63 m tall and weighed 90...

A 20-year-old man presented with a 6-month history of lethargy and weakness. His brother had been found to have adrenal failure at the age of 18. He had two sisters who were well and there was no other family history of endocrine autoimmune disease. On examination, his blood pressure was...

A 54-year-old woman was referred for assessment of low bone mineral density. Three months previously, after complaining of bloating and flatulence, she had been found to have coeliac disease and had been started on a gluten-free diet. She had no history of fracture and had not lost height. There was...

A 36-year-old man of South Asian origin presented acutely with a widespread pruritic rash involving the extensor surfaces of the limbs. On examination, he was moderately obese with a body mass index of 33 kg/m2 (18C25), and the rash was erythematous, with multiple small papules with yellow centres. Investigations: fasting...